Especially for ageing aircraft the development of fatigue cracks at fastener holes due to stress concentration and varying loading conditions constitutes a significant maintenance problem. High frequency guided waves offer a potential compromise between the capabilities of local bulk ultrasonic measurements with proven defect detection sensitivity and the large area coverage of lower frequency guided ultrasonic waves. High frequency guided waves have energy distributed through all layers of the specimen thickness, allowing in principle hidden (2nd layer) fatigue damage monitoring. For the integration into structural health monitoring systems the sensitivity for the detection of hidden fatigue damage in inaccessible locations of the multi-layered components from a stand-off distance has to be ascertained. The multi-layered model structure investigated consists of two aluminium plate-strips with an epoxy sealant layer. During cyclic loading fatigue crack growth at a fastener hole was monitored. Specific guided wave modes (combination of fundamental A0 and S0 Lamb modes) were selectively excited above the cut-off frequencies of higher modes using a standard ultrasonic wedge transducer. Non-contact laser measurements close to the defect were performed to qualify the influence of a fatigue crack in one aluminium layer on the guided wave scattering. Fatigue crack growth monitoring using laser interferometry showed good sensitivity and repeatability for the reliable detection of small, quarter-elliptical cracks. Standard ultrasonic pulse-echo equipment was employed to monitor hidden fatigue damage from a stand-off distance without access to the damaged specimen layer. Sufficient sensitivity for the detection of fatigue cracks located in the inaccessible aluminium layer was verified, allowing in principle practical in situ ultrasonic monitoring of fatigue crack growth.