Psychological disorders are often associated with a lack of inhibitory and interference control. In this paper, we present the software architecture design of a configurable serious game dedicated to inhibitory and interference control tests. The proposed architecture is based on generic components that are reusable across different game platforms and modes. Our design enables mental health practitioners to easily configure the serious game to adapt it to their test objectives and patients’ profile. The proposed game facilitates the tracking and analysis of inhibitory and interference control and their evolution over time, as data is logged over different gaming sessions. As a proof of concept, we implement a pilot application based on the proposed architecture, in both the 2D and VR modes. The developed application implements a gamified Stop Signal task (SST) augmented with interferences. We report the results of an empirical study assessing the perceived usability of the 2D and VR pilot games, using a standard usability test.