An intelligent packaging might, among others, provide information and allow monitoring of the quality of the packed product or its surrounding environment. A recent project on micro-flow wine bottles closed with aluminium screw cap and tightness liner, highlighted the importance of monitoring the internal overpressure continuously, in real-time and for several hours, as the internal pressure on the tightness liner and the micro-flow are related. Real-time and continuously control are not the standard methods of measurement for the overpressure. The most used equipment for the determination of the pressure in wine bottle is the aphrometer, a destructive device that supplies a single value of pressure. This paper describes a new intelligent measurement prototype that permits real-time and continuous control of the headspace pressure in wine bottles. The prototype is composed of two parts. The first part, introduced into the headspace of the bottle, is composed by one low-volume transmitting module (4.5cm3) and one measurement system for the temperature and pressure (7 bar max). The second part (outside of the bottle) is composed of one datareceiving module and one acquisition module. In the first test series, an overpressure is generated inside the bottles with dry ice (that melting increased pressure from 0.5 to 3.0 bar). A linear correlation between the aphrometer results and the prototype results is showed, confirming the correctness of the new device measurements. In the second test series, industrial tests are performed by integrating an industrial conditioning wine production line. The prototypes are installed inside the wine bottles in order to successfully determine the internal overpressures in bottles.