Electrically driven microengineered bioinspired soft robots

Shin, Su Ryon (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Migliori, Bianca (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA ; Department of Neuroscience Karolinska Institutet, Stockholm, Sweden) ; Miccoli, Beatrice (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA ; Department of Electronics and Telecommunication Politecnico di Torino, Italy) ; Li, Yi-Chen (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Mostafalu, Pooria (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Seo, Jungmok (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA ; Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology, Korea) ; Mandla, Serena (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Enrico, Alessandro (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA ; Department of Micro and Nanosystems KTH Royal Institute of Technology Stockholm, Sweden) ; Antona, Silvia (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Sabarish, Ram (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Zheng, Ting (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Pirrami, Lorenzo (School of Engineering and Architecture (HEIA-FR), HES-SO // University of Applied Sciences Western Switzerland ; Department of Electronics and Telecommunication Politecnico di Torino, Torino, Italy) ; Zhang, Kaizhen (Department of Mechanical and Industrial Engineering Northeastern University Boston, USA) ; Zhang, Yu Shrike (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Wan, Kai-Tak (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA) ; Demarchi, Danilo (Department of Electronics and Telecommunication Politecnico di Torino, Torino, Italy) ; Dokmeci, Mehmet R. (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA) ; Khademhosseini, Ali (Biomaterials Innovation Research Center Division of Engineering in Medicine Brigham and Women’s Hospital Harvard Medical School Boston, USA ; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge, USA)

To create life-like movements, living muscle actuator technologies have borrowed inspiration from biomimetic concepts in developing bioinspired robots. Here, the development of a bioinspired soft robotics system, with integrated self-actuating cardiac muscles on a hierarchically structured scaffold with flexible gold microelectrodes is reported. Inspired by the movement of living organisms, a batoid-fish-shaped substrate is designed and reported, which is composed of two micropatterned hydrogel layers. The first layer is a poly(ethylene glycol) hydrogel substrate, which provides a mechanically stable structure for the robot, followed by a layer of gelatin methacryloyl embedded with carbon nanotubes, which serves as a cell culture substrate, to create the actuation component for the soft body robot. In addition, flexible Au microelectrodes are embedded into the biomimetic scaffold, which not only enhance the mechanical integrity of the device, but also increase its electrical conductivity. After culturing and maturation of cardiomyocytes on the biomimetic scaffold, they show excellent myofiber organization and provide self-actuating motions aligned with the direction of the contractile force of the cells. The Au microelectrodes placed below the cell layer further provide localized electrical stimulation and control of the beating behavior of the bioinspired soft robot.


Article Type:
scientifique
Faculty:
Ingénierie et Architecture
School:
HEIA-FR
Institute:
IPRINT - Institut de printing
Subject(s):
Ingénierie
Date:
2018-01
Pagination:
13 p.
Published in:
Advanced Materials
Numeration (vol. no.):
2018, vol. 30, no.10
ISSN:
0935-9648
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2019-01-29, last modified 2019-02-05

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