PET-based prognostic survival model after radiotherapy for head and neck cancer : responsibility, individual consumption and demand-side policies in European deep decarbonisation pathways

Castelli, Joël (Radiotherapy Department, Cancer Institute Eugène Marquis, Rennes, France) ; Depeursinge, Adrien (University of Applied Sciences and Arts Western Switzerland (HES-SO Valais-Wallis)) ; Devillers, A (Nuclear Medicine DepartmentCancer Institute Eugène Marquis, Rennes, France) ; Campillo-Gimenez, B. (INSERM, U1099, Rennes, France) ; Dicente, Y (EPFL, Lausanne; University of Geneva, Geneva, Switzerland) ; Prior, J. O. (Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital, Lausanne, Switzerland) ; Chajon, E. (Radiotherapy Department, Cancer Institute Eugène Marquis, Rennes, France) ; Jegoux, F. (Head and Neck Department, CHU Rennes, Rennes, France) ; Sire, C. (Radiotherapy Department, Lorient Hospital, Lorient, France) ; Acosta, O. (INSERM, U1099, Rennes, France) ; Gherga, E. (Radiotherapy Department, CHU Besançon, Besançon, France) ; Sun, X. (Radiotherapy Department, CHU Besançon, Besançon, France) ; De Bari, B. (Radiotherapy Department, Hôpital Nord Franche Comté Montbéliard, Montbéliard, France) ; de Crevoisier, R. (Radiotherapy Department, Cancer Institute Eugène Marquis, Rennes, France)

Purpose The aims of this multicentre retrospective study of locally advanced head and neck cancer (LAHNC) treated with definitive radiotherapy were to (1) identify positron emission tomography (PET)- 18 F-fluorodeoxyglucose ( 18 F-FDG) parameters correlated with overall survival (OS) in a training cohort, (2) compute a prognostic model, and (3) externally validate this model in an independent cohort. Materials and methods A total of 237 consecutive LAHNC patients divided into training ( n = 127) and validation cohorts ( n = 110) were retrospectively analysed. The following PET parameters were analysed: SUV Max , metabolic tumour volume (MTV), total lesion glycolysis (TLG), and SUV Mean for the primary tumour and lymph nodes using a relative SUV Max threshold or an absolute SUV threshold. Cox analyses were performed on OS in the training cohort. The c-index was used to identify the highly prognostic parameters. A prognostic model was subsequently identified, and a nomogram was generated. The model was externally tested in the validation cohort. Results In univariate analysis, the significant PET parameters for the primary tumour included MTV (relative thresholds from 6 to 83% and absolute thresholds from 1.5 to 6.5) and TLG (relative thresholds from 1 to 82% and absolute thresholds from 0.5 to 4.5). For the lymph nodes, the significant parameters included MTVand TLG regardless of the threshold value. In multivariate analysis, tumour site, p16 status, MTV35% of the primary tumour, and MTV44% of the lymph nodes were independent predictors of OS. Based on these four parameters, a prognostic model was identified with a c-index of 0.72. The corresponding nomogram was generated. This prognostic model was externally validated, achieving a c-index of 0.66. Conclusions A prognostic model of OS based on primary tumour and lymph node MTV, tumour site, and p16 status was proposed and validated. The corresponding nomogram may be used to tailor individualized treatment

Article Type:
Economie et Services
Institut Informatique de gestion
Published in:
European journal of nuclear medicine and molecular imaging
Numeration (vol. no.):
March 2019, vol. 46, no. 3, pp. 638–649
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 Record created 2019-03-29, last modified 2020-10-27

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