TUCUXI : an intelligent system for personalized medicine from individualization of treatments to research databases and back

Dubovitskaya, Alevtina (School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland ; Swiss Federal Institute of Technology) ; Buclin, Thierry (University Hospital, Lausanne, Switzerland) ; Schumacher, Michael Ignaz (University of Applied Sciences and Arts Western Switzerland (HES-SO Valais-Wallis)) ; Aberer, Karl (Swiss Federal Institute of Technology, Lausanne, Switzerland) ; Thoma, Yann (School of Management and Engineering Vaud, HES-SO // University of Applied Sciences Western Switzerland)

Therapeutic Drug Monitoring (TDM) is a key concept in precision medicine. The goal of TDM is to avoid therapeutic failure or toxic effects of a drug due to insufficient or excessive circulating concen-tration exposure related to between-patient variability in the drug’s disposition. We present TUCUXI – an intelligent system for TDM. By making use of embedded mathematical models, the software allows to compute maximum likelihood individual predictions of drug concentrations from population pharmacokinetic data, based on patient’s parameters and previously observed concentrations. TUCUXI was developed to be used in medical practice, to assist clinicians in taking dosage adjustment decisions for optimizing drug concentration levels. This software is currently being tested in a University Hospital. In this paper we focus on the process of software integration in clinical work ow. The modular architecture of the software allows us to plug in a module enabling data aggregation for research purposes. This is an important feature in order to develop new mathematical models for drugs, and thus to improve TDM. Finally we discuss ethical issues related to the use of an automated decision support system in clinical practice, in particular if it allows data aggregation for research purposes.


Keywords:
Conference Type:
full paper
Faculty:
Ingénierie et Architecture
School:
HEIG-VD
Institute:
ReDS - Reconfigurable & embedded Digital Systems
Subject(s):
Ingénierie
Publisher:
Boston, Massachusetts, USA, 20-23 August 2017
Date:
2017-08
Boston, Massachusetts, USA
20-23 August 2017
Pagination:
10 p.
Published in:
Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, 20-23 August 2017, Boston, Massachusetts, USA
Numeration (vol. no.):
pp. 223-232
DOI:
ISBN:
978-1-4503-4722-8
External resources:
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2019-04-23, last modified 2019-04-23

Fulltext:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)