Improving pleasure and motivation in schizophrenia : a randomized controlled clinical trial

Favrod, Jérôme (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Nguyen, Alexandra (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Chaix, Joséphine (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Pellet, Joanie (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Frobert, Laurent (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Fankhauser, Caroline (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne;) ; Ismailaj, Alban (SISP SA, Lausanne, Switzerland;) ; Brana, Armando (HorizonSud, Marsens, Switzerland) ; Tamic, Gwennaïg (Fondation Stanislas, Montherod, Switzerland) ; Suter, Caroline (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Rexhaj, Shyrete (La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Golay, Philippe (Community Psychiatry Service, Department of Psychiatry, University Hospital Centre, Lausanne, Switzerland) ; Bonsack, Charles (Community Psychiatry Service, Department of Psychiatry, University Hospital Centre, Lausanne, Switzerland)

Background: Negative symptoms are frequent in patients with schizophrenia and are associated with marked impairments in social functioning. The efficacy of drug-based treatments and psychological interventions on primary negative symptoms remains limited. The Positive Emotions Programme for Schizophrenia (PEPS) is designed to improve pleasure and motivation in schizophrenia patients by target- ing emotion regulation and cognitive skills relevant to apathy and anhedonia. The main hypothesis of this study is that patients who attend 8 one-hour sessions of PEPS and treat- ment as usual (TAU) will have lower total apathy-avolition and anhedonia-asociality composite scores on the Scale for the Assessment of Negative Symptoms (SANS) than patients who attend only TAU. Methods: Eighty participants diagnosed with schizophrenia or schizoaffective disorder were andomized to receive either TAU or PEPS + TAU. The participants were assessed by independent evaluators before randomization (T0), in a post-test after 8 weeks of treatment (T1) and at a 6-month follow-up (T2). Results: The post-test results and 6-month follow-up assessments according to an intention-to-treat analysis showed that the apathy and anhedonia composite scores on the SANS indicated statistically greater clinical improvements in PEPS participants than in non-PEPS participants. In the post-test, anhedonia but not apathy was significantly improved, thus favouring the PEPS condition. These results were sustained at the 6-month follow-up. Conclusions: PEPS is an effective intervention to reduce anhedonia in schizophrenia. PEPS is a short, easy-to-use, group-based, freely available intervention that is easy to implement in a variety of environments


Keywords:
Article Type:
scientifique
Faculty:
Santé
School:
La Source
Institute:
Secteur Recherche et Développement (Ra&D) de l'Institut et Haute Ecole de la Santé La Source
Subject(s):
Santé
Date:
2019-01
Pagination:
12 p.
Published in:
Psychotherapy and Psychosomatics
Numeration (vol. no.):
2019, vol. 88, p. 84-95
DOI:
ISSN:
0033-3190
Appears in Collection:



 Record created 2019-05-27, last modified 2019-06-04

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