Neighbourhood socioeconomic deprivation and allostatic load : a multi-cohort study

Ribeiro, Ana Isabel (EPIUnit - Instituto de Saúde Pública, Universidade do Porto, 4050-600, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal) ; Fraga, Silvia (EPIUnit - Instituto de Saúde Pública, Universidade do Porto, 4050-600, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal) ; Kelly-Irving, Michelle (INSERM, Toulouse, France, and Université Toulouse III Paul-Sabatier, Toulouse, France.) ; Delpierre, Cyrille (INSERM, Toulouse, France, and Université Toulouse III Paul-Sabatier, Toulouse, France) ; Stringhini, Silvia (Institute of Social and Preventive Medicine, Lausanne University Hospital, Biopôle 2, Lausanne, Switzerland) ; Kivimaki, Mika (University College London, Department of Epidemiology and Public Health, London, UK. Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland) ; Joost, Stéphane (Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland; Laboratory of Geographic Information Systems (LASIG), School of Architecture, Civil and Environmental Engineering (ENAC), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland; GIRAPH Lab (Geographic information for research and analysis in public health), Geneva, Switzerland; La Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts of Western Switzerland, Lausanne) ; Guessous, Idris (Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland; GIRAPH Lab (Geographic information for research and analysis in public health), Geneva, Switzerland) ; Gandini, Martina (Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco, (TO), Italy) ; Vineis, Paolo (MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK)

Living in deprived neighbourhoods may have biological consequences, but few studies have assessed this empirically. We examined the association between neighbourhood deprivation and allostatic load, a biological marker of wear and tear, taking into account individual’s socioeconomic position. We analysed data from three cohort studies (CoLaus-Switzerland; EPIPorto-Portugal; Whitehall IIUK) comprising 16,364 participants. We defined allostatic load using ten biomarkers of dysregulated metabolic, cardiovascular, and inflammatory systems (body mass index; waist circumference; total, high and low density lipoprotein cholesterol; triglycerides; glucose; systolic and diastolic blood pressure; C-reactive protein). Mixed Poisson regression models were fitted to examine associations with neighbourhood deprivation (in quintiles, Q1-least deprived as reference). After adjustment for confounding variables, participants living in the most deprived quintile had 1.13 times higher allostatic load than those living in the least deprived quintile (Relative Risk, RR, for Q2 RR = 1.06, 95% CI 1.03- 1.09; Q3 = 1.06, 1.03–1.10; Q4 = 1.09, 1.06–1.12; Q5 = 1.13, 1.09–1.16). This association was partially modified by individual’s socioeconomic position, such that the relative risk was higher in participants with low socioeconomic position (Q5 vs Q1 1.16, 1.11–1.22) than those with high socioeconomic position (Q5 vs Q1 1.07, 1.01–1.13). Neighbourhood deprivation is associated with biological wear and tear, suggesting that neighbourhood-level interventions may yield health gains.


Keywords:
Article Type:
scientifique
Faculty:
Santé
School:
La Source
Institute:
Secteur Recherche et Développement (Ra&D) de l'Institut et Haute Ecole de la Santé La Source
Subject(s):
Santé
Date:
2019-06
Pagination:
11 p.
Published in:
Scientific Reports
Numeration (vol. no.):
2019, vol. 9, no 1, p.8790
DOI:
ISSN:
2045-2322
Appears in Collection:



 Record created 2019-07-05, last modified 2019-09-12

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