Evaluating hyperpolarized lactate as a theranostic agent for stroke

Hyacinthe, Jean-Noël (Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland ; University of Geneva, Geneva, Switzerland) ; Buscemi, Lara (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) ; Lepore, Mario (Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland) ; Gruetter, Rolf (Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland ; University of Geneva, Geneva, Switzerland ; University of Lausanne, Lausanne, Switzerland) ; Hirt, Lorenz (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) ; Mishkovsky, Mor (Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland)

Stroke is the leading cause of disability and the third leading cause of death worldwide. Lactate administration into the ischemic brain directly after blood reperfusion was found to be neuroprotective. MR with hyperpolarized (HP) probes enables in vivo realtime measurement of biochemical transformations of HP C-labeled precursors, including lactate. The aim of this study was to demonstrate the feasibility of probing HP [1- C]L-lactate metabolism in mice brain after ischemic stroke, and to study the influence of the time window after reperfusion on its conversion in order to evaluate the potential of HP lactate as a theranostic agent for stroke.


Conference Type:
short paper
Faculty:
Santé
School:
HEdS - Genève
Institute:
Aucun institut
Publisher:
Paris, France, 16-21 June 2018
Date:
2018-06
Paris, France
16-21 June 2018
Pagination:
4 p.
Published in:
Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2018
Numeration (vol. no.):
2018, pp. 1-4
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2019-07-18, last modified 2019-07-19

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