Impaired social cognition in schizophrenia during the Ultimatum Game : an EEG study

Horat, Sibylle K. (Laboratory for Psychiatric Neuroscience and Psychotherapy, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland) ; Favre, Grégoire (Sector of Psychiatry and Psychotherapy for Adults, Mental Health Network Fribourg (RFSM), Marsens, Switzerland) ; Prévot, Anne (School of Health Sciences, HES-SO Fribourg) ; Ventura, Joseph (Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (UCLA), Los Angeles, CA, USA) ; Herrmann, François R. (Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (UCLA), Los Angeles, CA, USA) ; Gothuey, Isabelle (Sector of Psychiatry and Psychotherapy for Adults, Mental Health Network Fribourg (RFSM), Marsens, Switzerland) ; Merlo, Marco C.G. (Laboratory for Psychiatric Neuroscience and Psychotherapy, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland) ; Missonnier, Pascal (Laboratory for Psychiatric Neuroscience and Psychotherapy, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland ; Sector of Psychiatry and Psychotherapy for Adults, Mental Health Network Fribourg (RFSM), Marsens, Switzerland)

Background: Schizophrenia has a core feature of cognitive dysfunctions. Since these deficits are predictive for patients' functional outcome, understanding their origin is of great importance to improve their daily lives. A specific component of the deficit involves social decision-making, which can be studied using the Ultimatum Game (UG). In this task, a “proposer” proposes a share of money to a “responder”, who can either accept or reject this offer. If the responder accepts the proposal, both win money. If the responder refuses, both players end up with nothing. Therefore, the UG evaluates decision-making strategies and social interaction. Methods:Wecompared the neuronal bases of schizophrenic patientswith healthy controls,while performing the UG. Electroencephalography (EEG) was used to find differences in the event-related potential (ERP) components typical for the UG, namely the P2 and feedback-related negativity (FRN). Source reconstruction was further used to define the origin of these differences. Results: In the proposer condition, no differenceswere found in amplitude of the P2 and FRN components. In contrast, in the responder condition, significant differences were found for the amplitude of the FRN (p = 0.009). Using source reconstruction, a different activation in a border zone of the dorsolateral and the medial prefrontal cortex was revealed in schizophrenic patients to underlie this component. Conclusions: We suggest that the difference found in the FRN amplitude is associated with difficulties of patients in interpreting another's behavior. Although schizophrenic patients correctly activate neuronal bases in the proposer condition, they were not able to activate the same networks in the responder condition, thereby exposing their difficulties in social interaction.


Keywords:
Article Type:
scientifique
Faculty:
Santé
School:
HEdS-FR
Institute:
Recherche appliquée et développement Santé HEDS-FR
Date:
2018-02
Pagination:
9 p.
Published in:
Schizophrenia Research
Numeration (vol. no.):
2018, vol. 192, pp. 308-316
DOI:
ISSN:
0920-9964
Appears in Collection:



 Record created 2019-11-28, last modified 2020-01-23

Fulltext:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)