Choroidal blood flow after the first intravitreal ranibizumab injection in neovascular age-related macular degeneration patients

Mottet, Benjamin (Grenoble Alpes University, Grenoble, France ; Department of Ophtalmology, University Hospital, CHU Grenobles-Alpes, Grenoble, France) ; Aptel, Florent (Grenoble Alpes University, Grenoble, France ; Department of Ophtalmology, University Hospital, CHU Grenoble-Alpes, Grenoble France ; INSERM U1042, Lab Hypoxia and Physiopathology, Grenoble-Alpes University, Grenoble, France) ; Geiser, Martial Henri (School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland) ; Hera, Ruxandra (Department of Ophtalmology, University Hospital, CHU Grenoble-Alpes, Grenoble, France) ; Zhou, Thierry (Grenoble Alpes University, Grenoble, France ; Department of Ophtalmology, University Hospital CHU Grenoble-Alpes, Grenoble, France) ; Almanjoumi, Ahmed (Department of Ophtalmology, University Hospital, CHU Grenoble-Alpes, Grenoble, France) ; Vinh, Viviane (Department of Ophtalmology, University Hospital, CHU Grenoble-Alpes, Grenoble, France) ; Chiquet, Christophe (Grenoble Alpes University, Grenoble, France ; Department of Ophtalmology, University Hospital CHU Grenoble-Alpes, Grenoble, France ; INSERM U1042, Lab Hypoxia and Physiopathology, Grenoble-Alpes University, Grenoble, France)

Purpose To analyse choroidal blood flow (ChBF) changes after the first intravitreal ranibizumab injection in naïve, age‐related macular degeneration (ARMD) patients. Methods Subfoveal ChBF was assessed by laser Doppler flowmetry (LDF) in newly diagnosed ARMD patients. Both treated and untreated eyes were assessed in each subject at each visit before the first intravitreal ranibizumab injection as well as 24 hr (day 1) and 7 days after (day 7). Central macular thickness (CMT), best‐corrected visual acuity (BVCA), systemic haemodynamic parameters and LDF parameters were evaluated at each visit. Nonparametric tests were used to compare data between visits and between treated and untreated eyes. Results Seventeen ARMD patients were included (12 women and five men, 78 ± 8 years old). At day 7 postintravitreal ranibizumab injection, the normalized choroidal blood velocity (ChBVel) change in the treated eye group was significant (−10.2%; p = 0.006). The choroidal blood volume (ChBVol) did not change significantly after intravitreal injection of ranibizumab. There was a trend for a reduction in ChBF at day 7 (−9.1%, p = 0.08). The sensitivity of the experiment was 12% for ChBVel, 16% for ChBVol and 9% for ChBF. Conclusion In conclusion, the laser Doppler technique provides feasible and noninvasive measurements of blood flow parameters before and after intravitreal injection of antivascular endothelial growth factor (anti‐VEGF) in patients with exudative ARMD. Choroidal blood velocity decreased as early as 7 days after intravitreal ranibizumab injection, suggesting a vasoconstriction effect of anti‐VEGF in large choroidal vessels in front of choriocapillaris (the site of LDF measurement).


Keywords:
Article Type:
scientifique
Faculty:
Ingénierie et Architecture
School:
HEI-VS
Institute:
Institut Systèmes industriels
Date:
2018-11
Pagination:
6 p.
Published in:
Acta Ophthalmologica
Numeration (vol. no.):
2018, vol. 96, no. 7, pp. e783-e788
DOI:
ISSN:
1755-375X
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2019-12-10, last modified 2019-12-17

Fulltext:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)