DisProt : intrinsic protein disorder annotation in 2020

Hatos, András (University of Padova, Italy) ; Hajdu-Soltész, Borbála (Eötvös Loránd University, Budapest, Hungary) ; Monzon, Alexander M. (University of Padova, Italy) ; Palopoli, Nicolas (Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires, Argentina) ; Gobeill, Julien (Haute école de gestion de Genève, HES-SO // Haute Ecole Spécialisée de Suisse Occidentale) ; Pasche, Emilie (Haute école de gestion de Genève, HES-SO // Haute Ecole Spécialisée de Suisse Occidentale) ; Ruch, Patrick (Haute école de gestion de Genève, HES-SO // Haute Ecole Spécialisée de Suisse Occidentale)

The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the ‘dark’ proteome.


Article Type:
scientifique
Faculty:
Economie et Services
School:
HEG - Genève
Institute:
CRAG - Centre de Recherche Appliquée en Gestion
Subject(s):
Sciences de l'information
Date:
2020-01
Pagination:
8 p.
Published in:
Nucleic Acids Research
Numeration (vol. no.):
2020, vol. 48, no D1, pp. D269–D276
DOI:
ISSN:
0305-1048
Appears in Collection:



 Record created 2020-01-16, last modified 2020-01-23

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