Device for silent substitution excitation of melanopsin for human eye

Agrici, Sergiu (University of Modena and Reggio Emilia, Italy ; School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland) ; Truffer, Frederic (School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland) ; Geiser, Martial (School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland) ; Balachandran, Chirojean (ENSA, France) ; Kawasaki, Aki (Hospital Jules Gonin, Lausanne, Switzerland)

Research in neurobiology has identified a new ocular photoreceptor (melanopsin or ipRGC) which mediates a variety of light-based, non-visual effects on human physiology. One way to isolate the stimulation of ipRGCs is the silent substitution technique. We have built a Maxwellian view device capable of 85% ipRGCs contrast excitation with a large FOV (52o). Four modulated LED light sources, illuminate a diffusing sphere, which exit aperture is imaged into the pupil of the eye. A camera with a 900 nm illumination capture the pupil. Without luminance changes (510±2 lm/m2), we increased ipRGC excitation from low to high level on three subjects. We observed a pupil constriction increasing with the ipRGC contrast. This suggests that we excite melanopsin silently. However, further experiments with electrophysiological and pupil recording needs to be done to completely validate our silent substitution device.


Keywords:
Conference Type:
full paper
Faculty:
Ingénierie et Architecture
School:
HEI-VS
Institute:
Institut Systèmes industriels
Publisher:
San Francisco, California, United States, 2-7 February 2019
Date:
2019-02
San Francisco, California, United States
2-7 February 2019
Pagination:
7 p.
Published in:
Proceedings volume 10858, Ophtalmic technologies XXIX, 1085813 (2019) ; Proceedings of SPIE BiOS, 2-7 February 2019, San Francisco, California, United States
DOI:
ISBN:
9781510623583
Appears in Collection:



 Record created 2020-01-21, last modified 2020-01-21

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