Fabrication of a geometrically complex brain slice perfusion device via contact liquid photolithographic polymerization (CLiPP)

Haraldsson, Klas Tommy (KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Stockholm, Sweden) ; Passeraub, Philippe (School of Engineering, Architecture and Landscape (hepia), HES-SO // University of Applied Sciences Western Switzerland)

In this contribution, a new method for the fabrication of complex polymeric microfluidic devices is presented. The technology has three distinct features : (i) liquid photoresists in contact with the phomask, (ii) readily removed sacrificial materials, and (iii) living radical processes, enable multiple polymeric chemistries and mechanical properties while simultaneously enabling facile fabrication of 3D geometries and surface chemistry control. This contribution details Contact Liquid Photolithographic Polymerization (CLiPP) fabrication techniques that are utilized for the fabrication of a geometrically complex brain slice perfusion device, which has several distinct and unique features such as (i) facile connections to auxiliary equipment, (ii) large unobstructed areas that allow access for a variety of detection equipment, e.g. conventional glass-pulled microelectrode even in restricted areas below microscopes, (iii) unique perfusion structures for optimized nutrient and waste transport and (iv) separated perfusion and drug fluid streams.


Keywords:
Conference Type:
short paper
Faculty:
Ingénierie et Architecture
School:
HEPIA - Genève
Institute:
inSTI - Institut des Sciences et Technologies industrielles
Publisher:
Karlsruhe, Germany, 29 June - 1st July 2005
Date:
2005-10
Karlsruhe, Germany
29 June - 1st July 2005
Pagination:
4 p.
Published in:
4M 2005: First International Conference on Multi-Material Micro Manufacture, 29 June - 1st July 2005, Karlsruhe, Germany
Numeration (vol. no.):
2005, p. 427-430
ISBN:
0-08-044879-8
Appears in Collection:



 Record created 2020-05-08, last modified 2020-11-10


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