Self-sampling to improve cervical cancer screening coverage in Switzerland : a randomised controlled trial

Viviano, Manuela (Department of Obstetrics and Gynecology, Geneva University Hospitals) ; Catarino, Rosa (Department of Obstetrics and Gynecology, Geneva University Hospitals) ; Jeannot, Emilien (Institute of Global Health–Faculty of Medicine ; Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland) ; Boulvain, Michel (Department of Obstetrics and Gynecology, Geneva University Hospitals) ; Undurraga Malinverno, Manuela (Department of Obstetrics and Gynecology, Geneva University Hospitals) ; Vassilakos, Pierre (Geneva Foundation for Medical Education and Research) ; Petignat, Patrick (Department of Obstetrics and Gynecology, Geneva University Hospitals)

Background: The aim of this study is to evaluate whether self-sampling can increase screening attendance of women who do not attend regular screening in Switzerland. Methods: Participants were proactively recruited in Geneva between September 2011 and November 2015. Women (25–69 years) who had not undergone CC screening in the last 3 years were considered eligible. Through a 1 : 1 ratio randomisation, enrolled participants were invited to either undergo liquid-based cytology, which was performed by a health-care provider (control group, CG) or to take a self-sample for HPV-testing, which was mailed to their home (intervention group, IG). Results: A total of 331 and 336 women were randomised in the CG and in the IG, respectively. Overall, 7.3% (95% CI: 4.9–10.6) women in the CG and 5.7% (95% CI: 3.6–8.7) women in the IG did not undergo the initial screening (P=0.400). There were 1.95% (95% CI: 0.8–4.3) women in the CG and 5.05% (95% CI: 3.1–8.1) women in the IG with a positive screen who did not attend triage and colposcopy (P=0.036). Conclusions: The participation in CC screening in women offered self-sampling was not higher than among those offered specimen collection by a clinician. Compliance with further follow-up for women with a positive HPV test on the self-sample requires further attention.


Keywords:
Article Type:
scientifique
Faculty:
Santé
School:
HEdS - Genève
Institute:
Aucun institut
Date:
2017-04
Pagination:
7 p.
Published in:
British Journal of Cancer
Numeration (vol. no.):
2017, vol. 116, no. 11, pp. 1382-1388
DOI:
ISSN:
0007-0920
Appears in Collection:



 Record created 2020-05-25, last modified 2020-05-26

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