Modulated 3D cross-correlation dynamic light scattering applications for optical biosensing and time-dependent monitoring of nanoparticle-biofluid interactions

Schintke, Silvia (School of Management and Engineering Vaud, HES-SO // University of Applied Sciences Western Switzerland) ; Frau, Eleonora (School of Management and Engineering Vaud, HES-SO // University of Applied Sciences Western Switzerland)

This paper reviews dynamic light scattering (DLS) of gold nanoparticle-protein interactions for the model protein bovine serum albumin (BSA), as well as in complex biofluids, at the example of mouse serum. DLS data of nanorods of various aspect ratio, of proteins and of mouse serum are discussed in terms of the analysis of their hydrodynamic radii, leading to the distinction of rotational and translational motion as well as to the detection of agglomerates. We address in particular advances obtained by modulated 3D cross correlation dynamic light scattering and recent progress using the CORENN algorithm for analysis of DLS data.


Keywords:
Article Type:
scientifique
Faculty:
Ingénierie et Architecture
School:
HEIG-VD
Institute:
COMATEC - Institut de Conception, Matériaux, Emballage & Conditionnement
Date:
2020-12
Pagination:
11 p.
Published in:
Applied Sciences
Numeration (vol. no.):
2020, vol. 10, no.24, article no. 8969
DOI:
ISSN:
2076-3417
Appears in Collection:



 Record created 2021-01-05, last modified 2021-01-07

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