UniProt : the universal protein knowledgebase in 2021

The UniProt Consortium (European Bioinformatics Institute (EMBL-EBI), Hinxton, UK ; Georgetown University Medical Center, Washington, USA ; University of Delaware, Newark, USA ; SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland) ; Ruch, Patrick (Haute école de gestion de Genève, HES-SO // Haute Ecole Spécialisée de Suisse Occidentale) ; Teodoro, Douglas (Haute école de gestion de Genève, HES-SO // Haute Ecole Spécialisée de Suisse Occidentale)

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.


Article Type:
scientifique
Faculty:
Economie et Services
School:
HEG - Genève
Institute:
CRAG - Centre de Recherche Appliquée en Gestion
Subject(s):
Sciences de l'information
Date:
2021-01
Pagination:
10 p.
Published in:
Nucleic Acids Research
Numeration (vol. no.):
2021, vol. 49, no. D1, pp. D480–D489
DOI:
ISSN:
0305-1048
Appears in Collection:



 Record created 2021-04-30, last modified 2021-05-14

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