SPECT-CT comparison of lung deposition using a system combining a vibrating-mesh nebulizer with a valved holding chamber and a conventional jet nebulizer : a randomized cross-over study

Dugernier, Jonathan (Institut de Recherche Expérimentale et Clinique (IREC), Pneumologie, ORL and Dermatologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; Soins Intensifs, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; Médecine Physique, Cliniques Universitaires Saint-Luc, Brussels, Belgium) ; Hesse, Michel (Médecine Nucléaire, Cliniques universitaires Saint-Luc, Brussels, Belgium) ; Vanbever, Rita (Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, Brussels, Belgium) ; Depoortere, Virginie (Médecine Nucléaire, Cliniques Universitaires Saint-Luc, Brussels, Belgium) ; Roeseler, Jean (Soins Intensifs, Cliniques Universitaires Saint-Luc, Brussels, Belgium) ; Michotte, Jean-Bernard (HESAV School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland) ; Laterre, Pierre-François (Soins Intensifs, Cliniques Universitaires Saint-Luc, Brussels, Belgium) ; Jamar, François (Médecine Nucléaire, Cliniques Universitaires Saint-Luc, Brussels, Belgium) ; Reychler, Gregory (Institut de Recherche Expérimentale et Clinique (IREC), Pneumologie, ORL and Dermatologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; Médecine Physique, Cliniques Universitaires Saint-Luc, Brussels, Belgium ; Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium)

Purpose: To compare in vivo the total and regional pulmonary deposition of aerosol particles generated by a new system combining a vibrating-mesh nebulizer with a specific valved holding chamber and constant-output jet nebulizer connected to a corrugated tube. Methods: Cross-over study comparing aerosol delivery to the lungs using two nebulizers in 6 healthy male subjects: a vibrating-mesh nebulizer combined with a valved holding chamber (Aerogen Ultra®, Aerogen Ltd., Galway, Ireland) and a jet nebulizer connected to a corrugated tube (OptiMist Plus Nebulizer®, ConvaTec, Bridgewater, NJ). Nebulizers were filled with diethylenetriaminepentaacetic acid labelled with technetium-99 m (99mTc-DTPA, 2 mCi/4 mL). Pulmonary deposition of 99mTc-DTPA was measured by single-photon emission computed tomography combined with a low dose CT-scan (SPECT-CT). Results: Pulmonary aerosol deposition from SPECT-CT analysis was six times increased with the vibrating-mesh nebulizer as compared to the jet nebulizer (34.1 ± 6.0% versus 5.2 ± 1.1%, p  0.001). However, aerosol penetration expressed as the three-dimensional normalized ratio of the outer and the inner regions of the lungs was similar between both nebulizers. Conclusions: This study demonstrated the high superiority of the new system combining a vibrating-mesh nebulizer with a valved holding chamber to deliver nebulized particles into the lungs as comparted to a constant-output jet nebulizer with a corrugated tube.


Keywords:
Article Type:
scientifique
Faculty:
Santé
Branch:
Physiothérapie
School:
HESAV
Institute:
Aucun institut
Date:
2017-01
Pagination:
11p.
Published in:
Pharmaceutical research
Numeration (vol. no.):
February 2017, vol. 34, no. 2, pp. 290-300
DOI:
ISSN:
0724-8741
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2021-05-07, last modified 2021-05-10

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