Biodegradable polymer–lipid monolayers as templates for calcium phosphate mineralization

Jagoda, Agnieszka (University of Basel, Basel, Switzerland) ; Zinn, Manfred (School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland) ; Bieler, Eva (University of Basel, Basel, Switzerland) ; Meier, Wolfgang (University of Basel, Basel, Switzerland) ; Kita-Tokarczyk, Katarzyna (University of Basel, Basel, Switzerland)

A combination of poly([R]-3-hydroxy-10-undecenoate) (PHUE), a biodegradable polymer from the group of polyhydroxyalkanoates (PHAs), and lipids of different head groups was used to support the growth of calcium phosphate, the main component of mammalian bones. Crystallization took place under two-dimensional films (Langmuir monolayers). The addition of a negatively charged lipid, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine, to a PHUE film led to the formation of lipid domains (rich in negative charge), and resulted in excellent mineralization control: crystals with uniform size and morphology were formed. The results show that carefully optimized combinations of materials can lead to better control of calcium phosphate crystallization compared to one-component organic scaffolds.


Article Type:
scientifique
Faculty:
Ingénierie et Architecture
School:
HEI-VS
Institute:
Institut Technologies du vivant
Date:
2012-11
Pagination:
11 p.
Published in:
Journal of Materials Chemistry B
Numeration (vol. no.):
2013, vol. 1, pp. 368-378
DOI:
ISSN:
2050-750X
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2021-07-02, last modified 2021-07-06

Fulltext:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)