Head group influence on lipid interactions with a polyhydroxyalkanoate biopolymer

Jagoda, Agniezska (University of Basel, Basel, Switzerland) ; Zinn, Manfred (School of Engineering, HES-SO Valais-Wallis, HEI, HES-SO // University of Applied Sciences Western Switzerland) ; Meier, Wolfgang (University of Basel, Basel, Switzerland) ; Kita-Tokarczyk, Katarzyna (University of Basel, Basel, Switzerland)

Poly([R]-3-hydroxy-10-undecenoate) (PHUE) is a biodegradable/biocompatible polyester from polyhydroxyalkanoates (PHAs) family, used in biomedical applications. PHA's introduction to the body may have implications on cell membrane stability—this motivates studies of interactions between PHAs and phospholipids, main membrane constituents. Interaction analysis in PHUE monolayers with two phospholipids (different hydrophilic groups), phosphatidylserine (DOPS), and phosphatidylethanolamine (DOPE), shows that repulsive interactions between PHUE and DOPS and attractive between PHUE and DOPE resulted from different lipid headgroup size and orientation at the air–water interface (PE, parallel to the interface, attracted PHUE via hydrogen bonds, ion–dipole, and dipole–dipole interactions).


Article Type:
scientifique
Faculty:
Ingénierie et Architecture
School:
HEI-VS
Institute:
Institut Technologies du vivant
Date:
2012-08
Pagination:
11 p.
Published in:
Macromolecular Chemistry and Physics
Numeration (vol. no.):
2012, vol. 213, no. 18, pp. 1922-1932
DOI:
ISSN:
10221352
Appears in Collection:

Note: The status of this file is: restricted


 Record created 2021-07-02, last modified 2021-07-08

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